ghrelin, food intake, and botanical extracts: a review

نویسندگان

peyman rezaie biochemistry of nutrition research center, school of medicine, mashhad university of medical sciences, mashhad, iran

mohsen mazidi institute of genetics and developmental biology, international college, university of chinese academy of science (ic-ucas), beijing, china

mohsen nematy biochemistry of nutrition research center, school of medicine, mashhad university of medical sciences, mashhad, iran

چکیده

a kind of growth hormone secretagogue (ghs), ghrelin, was first isolated from the rat stomach and plays a major role in the activation of the growth hormone secretagogue receptor 1a (ghs-r1a) resulting the release of growth hormone (gh). the preproghrelin gene is placed on chromosome 3, at locus 3p25 –2 in humans and constitutes five exons and three introns. ghrelin is most plentifully expressed in particular cells in the oxyntic glands of the gastric epithelium, initially named x/a-like cells. almost 60-70% of circulating ghrelin is secreted by the stomach. plasma ghrelin concentration alters throughout the day. ghrelin has been suggested to act as a meal initiator because of its appetite-stimulating influences in free feeding rats in short period. in addition to ghrelin’s function as a meal motivator, it seems to contribute in long-term energy balance and nutritional status. in addition, many studies have been carried out in order to investigate the effects of natural and medicinal plants and botanical extracts on appetite, food intake, energy hemostasis, and the level of related hormones including ghrelin. due to the importance of ghrelin in nutritional and medical sciences, this review was performed to understand new aspects of this hormone’s function.

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منابع مشابه

Ghrelin, food intake, and botanical extracts: A Review

A kind of growth hormone secretagogue (GHS), ghrelin, was first isolated from the rat stomach and plays a major role in the activation of the growth hormone secretagogue receptor 1a (GHS-R1a) resulting the release of growth hormone (GH). The preproghrelin gene is placed on chromosome 3, at locus 3p25 –2 in humans and constitutes five exons and three introns. Ghrelin is most plentifully expresse...

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Ghrelin, food intake, and botanical extracts: A Review

A kind of growth hormone secretagogue (GHS), ghrelin, was first isolated from the rat stomach and plays a major role in the activation of the growth hormone secretagogue receptor 1a (GHS-R1a) resulting the release of growth hormone (GH). The preproghrelin gene is placed on chromosome 3, at locus 3p25 -2 in humans and constitutes five exons and three introns. Ghrelin is most plentifully expresse...

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Ghrelin: a hormone regulating food intake and energy homeostasis.

Regulation of energy homeostasis requires precise coordination between peripheral nutrient-sensing molecules and central regulatory networks. Ghrelin is a twenty-eight-amino acid orexigenic peptide acylated at the serine 3 position mainly with an n-octanoic acid, which is produced mainly in the stomach. It is the endogenous ligand of the growth hormone secretagogue (GHS) receptors. Since plasma...

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Ghrelin and the regulation of food intake and energy balance.

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Ghrelin enhances appetite and increases food intake in humans.

Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. Ghrelin has been shown to promote increased food intake, weight gain and adiposity in rodents. The effect of ghrelin on appetite and food intake in man has not been determined. We investigated the effects ...

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Ghrelin, a 28-amino-acid peptide, has recently been isolated from the rat stomach as an endogenous ligand for the GH secretagogue receptor. We have reported previously that central or peripheral administration of ghrelin stimulates food intake, and the secretion of GH and gastric acid in rats. In the present study, we investigated how much endogenous centrally released ghrelin is involved in th...

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عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۵، شماره ۴، صفحات ۲۷۱-۲۸۱

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